Research
Main focus areas
01
Tissue engineering and organoid systems
We are at the forefront of innovative research in the realm of endometrial studies. Recently, we developed a synthetic hydrogel that serves as a remarkable alternative to Matrigel. This innovation has revolutionized our approach to organoid co-cultures of endometrial tissues. Our endometrium co-culture model, designed to mimic the menstrual cycle, provides a fully defined environment for dissecting the cellular and molecular hormone-mediated processes that govern this dynamic tissue. This enables us to delve deep into the mechanisms underpinning both physiological and pathological conditions.
02
Tissue clearing and 3D pathology
Within our lab, we embrace cutting-edge techniques like tissue clearing and 3D pathology to advance our research in understanding biological tissues. Tissue clearing is a transformative process that renders tissues transparent by removing light-scattering elements, allowing us to explore their intricate structures in three dimensions. This breakthrough technique, in conjunction with 3D pathology, enables us to gain comprehensive insights into tissue architecture and pathology.
03
Disease modeling- Endometriosis
In our lab, we focus on studying endometriosis, a condition that often flies under the radar despite its significant impact. Endometriosis is classified as a "benign" metastatic disease, yet it affects over 10% of women diagnosed, making it far from rare. This condition is closely associated with debilitating pelvic pain and infertility, making it an issue of profound concern for affected individuals. What further complicates the matter is the poor understanding of its pathophysiology, leading to a lack of targeted therapies. Endometriosis is characterized by estrogen dependence and a remarkable resistance to progesterone, making it a complex puzzle that we are dedicated to unraveling in our research endeavors.