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Main focus areas

Research Statement_3D tissue engineering and disease phenotyping


Tissue engineering and organoid systems 


We are at the forefront of innovative research in the realm of endometrial studies. Recently, we developed a synthetic hydrogel that serves as a remarkable alternative to Matrigel. This innovation has revolutionized our approach to organoid co-cultures of endometrial tissues. Our endometrium co-culture model, designed to mimic the menstrual cycle, provides a fully defined environment for dissecting the cellular and molecular hormone-mediated processes that govern this dynamic tissue. This enables us to delve deep into the mechanisms underpinning both physiological and pathological conditions.

Tissue engineering and organoid systems in synthetic gels
Synthetic Hydrogel alt to Matrigel ECM
Organoids closeup
Tissue clearing and 3D pathology


Tissue clearing and 3D pathology 

Within our lab, we embrace cutting-edge techniques like tissue clearing and 3D pathology to advance our research in understanding biological tissues. Tissue clearing is a transformative process that renders tissues transparent by removing light-scattering elements, allowing us to explore their intricate structures in three dimensions. This breakthrough technique, in conjunction with 3D pathology, enables us to gain comprehensive insights into tissue architecture and pathology.

Tissue clearing and Light sheet microscopy


Disease modeling- Endometriosis

In our lab, we focus on studying endometriosis, a condition that often flies under the radar despite its significant impact. Endometriosis is classified as a "benign" metastatic disease, yet it affects over 10% of women diagnosed, making it far from rare. This condition is closely associated with debilitating pelvic pain and infertility, making it an issue of profound concern for affected individuals. What further complicates the matter is the poor understanding of its pathophysiology, leading to a lack of targeted therapies. Endometriosis is characterized by estrogen dependence and a remarkable resistance to progesterone, making it a complex puzzle that we are dedicated to unraveling in our research endeavors.

Endometriotic Disease
Endometriotic Disease
Endometriotic Disease
Endometriotic Disease
Endometrium Disease Modeling
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